Are ongoing trials on hematologic malignancies still excluding older subjects?

vision of the possible mechanism(s) involved in the hemolytic crisis brought on by other comorbid conditions, such as sepsis. Along the same lines, there is evidence that the HbF levels, an important regulatory mechanism of SCA severity and hemolysis, govern MP concentration by acting on specific MP subtypes. We can imagine that, in SCA children, a storm of various (mainly platelet-derived) procoagulant MPs takes place with chronic hemolysis and is driven by HbF levels (Figure 1).